Figure 2: Trastuzumab emtansine (T-DM1) in action. The monoclonal antibody component helps T-DM1 locate the HER-2-neu positive cells. After internalization, the antibody component is recycled via the endosome. The antibody component is capable of causing cell death via downregulation, antibody-dependent cell cytotoxicity, complement-dependent cytotoxicity, and phagocytosis. The remaining portion of the conjugate undergoes lysosomal degradation. The cytotoxic component (emtansine) is capable of causing cell death via mitotic arrest, apoptosis, mitotic catastrophe, and disrupted intracellular trafficking