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Figure 5: Effect of SB365 on hypoxia-inducible factor-1 alpha expression under hypoxia. (a) Expression of hypoxia-inducible factor-1 alpha by SB365 was observed in hypoxia-induced A172 glioblastoma cells. (b) Production of vascular endothelial growth factor by SB365 was determined using sandwich ELISA in hypoxia-induced A172 cells for 24 h (CoCl2, 100 μM). Data from the triplicate wells are represented as mean ± standard deviation.###P < 0.001 versus control group; **P < 0.01 and ***P < 0.001 versus CoCl2 group

Figure 5: Effect of SB365 on hypoxia-inducible factor-1 alpha expression under hypoxia. (a) Expression of hypoxia-inducible factor-1 alpha by SB365 was observed in hypoxia-induced A172 glioblastoma cells. (b) Production of vascular endothelial growth factor by SB365 was determined using sandwich ELISA in hypoxia-induced A172 cells for 24 h (CoCl<sub>2</sub>, 100 μM). Data from the triplicate wells are represented as mean ± standard deviation.<sup>###</sup><i>P</i> < 0.001 versus control group; **<i>P</i> < 0.01 and ***<i>P</i> < 0.001 versus CoCl<sub>2</sub> group