Figure 3: Effect of ondansetron on (0.5 and 1 mg/kg, p.o.) treatment on histology of brain hippocampal DG region in high-fat diet-fed mice with hemotoxylin and eosin staining at ×10 and ×40, respectively. Escitalopram (10 mg/kg, p.o.) served as standard antidepressant group. Yellow arrows show the healthy neurons whereas red arrows represent the pyknotic neurons. Values represent mean ± standard error of the mean, ^##P < 0.01 as compared to normal pellet diet control group, **P < 0.01 as compared to high-fat diet control group