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Figure 1: Representative record of effects of L-NAME and ARL-17477 on spontaneous motor contractions of colonic tissues isolated from control and IBS.rats. L-NAME significantly increased the mean pressure in both control (a) and IBS (b) groups at concentration of 10-4 mol/L (P < 0.05). ARL-17477 significantly increased the mean pressure on only in the control (c) group at concentrations of 10-7 and 10-6 mol/L (P < 0.05); did not increase significant in IBS (d) group (P > 0.05). IBS: Irritable bowel syndrome

Figure 1: Representative record of effects of L-NAME and ARL-17477 on spontaneous motor contractions of colonic tissues isolated from control and IBS.rats. L-NAME significantly increased the mean pressure in both control (a) and IBS (b) groups at concentration of 10<sup>-4</sup> mol/L (<i>P</i> < 0.05). ARL-17477 significantly increased the mean pressure on only in the control (c) group at concentrations of 10<sup>-7</sup> and 10<sup>-6</sup> mol/L (<i>P</i> < 0.05); did not increase significant in IBS (d) group (<i>P</i> > 0.05). IBS: Irritable bowel syndrome