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Figure 3: Effect of acidosis on the blocking effect of prazosin on noradrenaline. and phenylephrine.induced concentration.related contractile response in goat superior mesenteric artery. (a-c) Noradrenaline (1 nM-100 μM)-induced concentration.related contractile response curve in the absence or presence of prazosin (1 nM, 10 nM, and 0.1 μM) elicited at pHo 7.4 (a), 6.0 (b), and 5.0 (c). (d-f) Phenylephrine (1 nM-100 μM).induced concentration.related contractile response curve in the absence or presence of prazosin (1 nM, 10 nM, and 0.1 μM) elicited at pHo 7.4 (d), 6.0 (e), and 5.0 (f). Data were expressed as mean gram tension ± standard error. *P < 0.05 versus nontreated group (control)

Figure 3: Effect of acidosis on the blocking effect of prazosin on noradrenaline. and phenylephrine.induced concentration.related contractile response in goat superior mesenteric artery. (a-c) Noradrenaline (1 nM-100 μM)-induced concentration.related contractile response curve in the absence or presence of prazosin (1 nM, 10 nM, and 0.1 μM) elicited at pH<sub>o</sub> 7.4 (a), 6.0 (b), and 5.0 (c). (d-f) Phenylephrine (1 nM-100 μM).induced concentration.related contractile response curve in the absence or presence of prazosin (1 nM, 10 nM, and 0.1 μM) elicited at pH<sub>o</sub> 7.4 (d), 6.0 (e), and 5.0 (f). Data were expressed as mean gram tension ± standard error. <i>*P</i> < 0.05 versus nontreated group (control)