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Figure 1: Effect of acidosis on α1 agonist (noradrenaline and phenylephrine)-induced vasocontraction in goat superior mesenteric artery. (a) Noradrenaline and phenylephrine (10 μM)-induced contractile response elicited in goat superior mesenteric artery maintained at pHo 7.4, 6.8, 6.0, 5.5, 5.0, and 4.5. * P < 0.05 versus pH 7.4 (control) in noradrenaline-induced contraction and # P < 0.05 versus pH 7.4 (control) in phenylephrine.induced contraction. (b and c) Noradrenaline and phenylephrine (10 μM)induced contractile response in endothelium intact (ED+) and denuded (ED−) goat superior mesenteric artery rings maintained at pHo 7.4, 6.0, and 5.0. Data were expressed as mean gram tension ± standard error. * P < 0.05 versus ED+ (control) in noradrenaline and phenylephrine (10 μM)-induced contraction

Figure 1: Effect of acidosis on α<sub>1</sub> agonist (noradrenaline and phenylephrine)-induced vasocontraction in goat superior mesenteric artery. (a) Noradrenaline and phenylephrine (10 μM)-induced contractile response elicited in goat superior mesenteric artery maintained at pHo 7.4, 6.8, 6.0, 5.5, 5.0, and 4.5. * <i>P</i> < 0.05 versus pH 7.4 (control) in noradrenaline-induced contraction and # <i>P</i> < 0.05 versus pH 7.4 (control) in phenylephrine.induced contraction. (b and c) Noradrenaline and phenylephrine (10 μM)induced contractile response in endothelium intact (ED+) and denuded (ED−) goat superior mesenteric artery rings maintained at pH<sub>o</sub> 7.4, 6.0, and 5.0. Data were expressed as mean gram tension ± standard error. * <i>P</i> < 0.05 versus ED+ (control) in noradrenaline and phenylephrine (10 μM)-induced contraction