Indian J Pharm Close
 

Figure 1: Peripheral antinociceptive effects of sildenafil on formalin test in rats. The animals were pretreated with Sildenafil (Sil, 25, 50, and 100 mcg/paw, i.pl.) or vehicle (VEH) 20 min before the administration of formalin (50 ìl, 2.5%) into the right (ipsilateral, IL) or left (contralateral, CL) hind paw. Time course (panel A) of the flinching number of paw was recorded at 0-5 min (fi rst phase, panel B) and 15- 60 min (second phase, panel C) after formalin injection. All data are expressed as mean ± S.E.M. (n = 8). *P < 0.05 compared with vehicle group (one-way ANOVA with Dunnettæs test)

Figure 1: Peripheral antinociceptive effects of sildenafil on formalin test in rats. The animals were pretreated with Sildenafil (Sil, 25, 50, and 100 mcg/paw, i.pl.) or vehicle (VEH) 20 min before the administration of formalin (50 ìl, 2.5%) into the right (ipsilateral, IL) or left (contralateral, CL) hind paw. Time course (panel A) of the flinching number of paw was recorded at 0-5 min (fi rst phase, panel B) and 15- 60 min (second phase, panel C) after formalin injection. All data are expressed as mean ± S.E.M. (<i>n</i> = 8). *<i>P</i> < 0.05 compared with vehicle group (one-way ANOVA with Dunnettæs test)