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Figure 3: H and E staining on the coronal section of cerebrum in in EAE and EAE induced animals which treated by different doses of A. millefolium. Digital images were collected under a bright-fi eld setting using a ×40 objective. (a) A1 is for sham, A2 = EAE, A3 = EAE+1 mg/ mouse A. millefolium, A4 = EAE+5 mg/mouse A. millefolium and A5 = EAE+10 mg/mouse A. millefolium groups. Arrows show infl ammatory infi ltrates. (b) Shows the infl ammation index (see methods) in different groups. *signifi cant difference between EAE and EAE+5 mg/mouse A. millefolium (p= 0.013). #signifi cant difference between EAE and EAE+10 mg/mouse A. millefolium (P= 0.01)

Figure 3: H and E staining on the coronal section of cerebrum in in EAE and EAE induced animals which treated by different doses of A. millefolium. Digital images were collected under a bright-fi eld setting
using a ×40 objective. (a) A1 is for sham, A2 = EAE, A3 = EAE+1 mg/ mouse A. millefolium, A4 = EAE+5 mg/mouse A. millefolium and A5 = EAE+10 mg/mouse A. millefolium groups. Arrows show infl ammatory
infi ltrates. (b) Shows the infl ammation index (see methods) in different groups. *signifi cant difference between EAE and EAE+5 mg/mouse A. millefolium (p= 0.013). #signifi cant difference between EAE and EAE+10 mg/mouse A. millefolium (P= 0.01)