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Figure 3: (a) Effect of vardenafil (10−7-10−6 M) on the cumulative-concentration curve induced by extracellular Ca+2 in endothelium-denuded pulmonary artery rings. Data are reported as mean ± standard error of the mean (SEM) of 12 rats. *P < 0.05 and **P < 0.01 versus control group. (b) Effect quinoxalin-1-one (ODQ) (10−4 M) incubation in the cumulative addition of CaCl2 (3 × 10−5-3 × 10−2 M). Results are presented as mean ± SEM of 12 rats. *P < 0.05 and **P < 0.01 versus group without ODQ incubation

Figure 3: (a) Effect of vardenafil (10<sup>−7</sup>-10<sup>−6</sup> M) on the cumulative-concentration curve induced by extracellular Ca<sup>+2</sup> in endothelium-denuded pulmonary artery rings. Data are reported as mean ± standard error of the mean (SEM) of 12 rats. *<i>P</i> < 0.05 and **<i>P</i> < 0.01 versus control group. (b) Effect quinoxalin-1-one (ODQ) (10<sup>−4</sup> M) incubation in the cumulative addition of CaCl<sub>2</sub> (3 × 10<sup>−5</sup>-3 × 10<sup>−2</sup> M). Results are presented as mean ± SEM of 12 rats. *<i>P</i> < 0.05 and **<i>P</i> < 0.01 versus group without ODQ incubation