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Figure 3: Effect of PQDS on the cell cycle and proliferation index of VSMCs. (a-f) are the representative data of the cell cycle analysis for (a) the control, (b) Ang II, (c) Ang II+PQDS (25 mg/L), (d) Ang II+PQDS (50 mg/L), (e) Ang II+PQDS (100 mg/L), and (f) Ang II+diltiazem (0.1 μM), determined by flow cytometry. The number of cells in the G0/G1 phase, the S phase (DNA synthesis phase), and the G2/M-phase (mitosis) are shown. (g) The percentage of cells in each phase using flow cytometry. The x-axis represents the doses of drugs. (h) The proliferation index of cells after PQDS or diltiazem treatment. The x-axis represents the drug doses used. #P< 0.05 compared to the control group; *P < 0.05 compared to the AngII treatment group; ^ P < 0.05 compared to the diltiazem treatment group

Figure 3: Effect of PQDS on the cell cycle and proliferation index of VSMCs. (a-f) are the representative data of the cell cycle analysis for (a) the control, (b) Ang II, (c) Ang II+PQDS (25 mg/L), (d) Ang II+PQDS (50 mg/L), (e) Ang II+PQDS (100 mg/L), and (f) Ang II+diltiazem (0.1 μM), determined by flow cytometry. The number of cells in the G0/G1 phase, the S phase (DNA synthesis phase), and the G2/M-phase (mitosis) are shown. (g) The percentage of cells in each phase using flow cytometry. The x-axis represents the doses of drugs. (h) The proliferation index of cells after PQDS or diltiazem treatment. The x-axis represents the drug doses used. #P< 0.05 compared to the control group; *P < 0.05 compared to the AngII treatment group; ^ P < 0.05 compared to the diltiazem treatment group