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Figure 3: Effects of ZIM (15 mg/kg; i.p.) on the development of morphine tolerance in the tail-fl ick (a) and hot-plate test (b). Each point represents the mean±SEM of percent of maximal possible effect (%MPE) for six rats. *P<0.001, **P<0.01 and ***P<0.05 compared to saline-treated group

Figure 3: Effects of ZIM (15 mg/kg; i.p.) on the development of morphine tolerance in the tail-fl ick (a) and hot-plate test (b). Each point represents the mean±SEM of percent of maximal possible effect (%MPE) for six rats. *<i>P</i><0.001, **<i>P</i><0.01 and ***<i>P</i><0.05 compared to saline-treated group