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Figure 1: Chemical structure and anti-HIV-1IIIB mechanism of PS20 (Cynanchum otophyllum glucan sulfate). (a) Chemical structure of Cynanchum otophyllum beta-D-(1-4)-glucan sulfate. (b) Time-of-addition experiment. (c) Inhibition of cell-cell fusion. C8166 cells and H9/HIV-1IIIB cells were co-cultured for 1 day in the presence of serially diluted PS20 or AZT. (d) Dose-response curves of PS20 anti-HIV-1IIIB activity in different pretreatments |
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