Figure 3 :(A) Duration of DPP-IV inhibition in vivo. ob/ob mice were given the inhibitors at 10 mg/kg (p.o), blood collected at 0, 1, 2, 4, 8, and 12 h and analyzed for DPP-IV activity. The values represent the mean ±S.E.M (n=9). (B) Duration of glucose lowering effect in vivo. % AUC change in glucose in ob/ob mice pre-dosed with the inhibitors at 10 mg/kg (p.o) followed by OGTT at 1, 4, 8, and 12 h. The values represent the mean ± S.E.M (n=9). Closed bar - sitagliptin; open bar - vildagliptin; group number depicted below the bar.