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Figure 2: Electron micrograph of rat myocardium of CTR group showed normal mitochondria (MI), myofibrils (MF), and nucleus (N) (A and B; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively), DOX treated group showing myofibrils with vacuoles and chromatins marginates (arrows) at nuclear membrane (C and D; magnification: 0.84 × 10,000 and 0.46 × 10,000 respectively), NAP PS group showed myofibrils integrity with slightly condensed chromatins marginates (arrows) at nuclear membrane (E and F; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively), TMZ PS group showed MI, N, and MF integrity (G and H; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively), DOX + NAP treated group showed cytoplasmic vacuolization, indented nucleus and condensed chromatin marginates at the nuclear membrane (I and J; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively), DOX + TMZ treated group showed normal mitochondria, myofibril integrity, and less extensive cytoplasmic vacuolization (K and L; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively), DOX + TMZ + NAP group showed normal myofibril arrangement and condensed chromatin marginates at the nuclear membrane (M and N; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively).

Figure 2: Electron micrograph of rat myocardium of CTR group showed normal mitochondria (MI), myofibrils (MF), and nucleus (N) (A and B; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively), DOX treated group showing myofibrils with vacuoles and chromatins marginates (arrows) at nuclear membrane (C and D; magnification: 0.84 × 10,000 and 0.46 × 10,000 respectively), NAP PS group showed myofibrils integrity with slightly condensed chromatins marginates (arrows) at nuclear membrane (E and F; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively), TMZ PS group showed MI, N, and MF integrity (G and H; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively), DOX + NAP treated group showed cytoplasmic vacuolization, indented nucleus and condensed chromatin marginates at the nuclear membrane (I and J; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively), DOX + TMZ treated group showed normal mitochondria, myofibril integrity, and less extensive cytoplasmic vacuolization (K and L; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively), DOX + TMZ + NAP group showed normal myofibril arrangement and condensed chromatin marginates at the nuclear membrane (M and N; magnification: 0.84 × 10,000 and 0.46 × 10,000, respectively).