IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Reader Login
Users Online : 2575 
Small font sizeDefault font sizeIncrease font size
Navigate Here
     My Preferences 
     Manuscript submission

 


Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
  Access statistics : Table of Contents
   1986| January-March  | Volume 18 | Issue 1  
 
 
  Archives   Previous Issue   Next Issue   Most popular articles   Most cited articles
 
Hide all abstracts  Show selected abstracts  Export selected to
  Viewed PDF Cited
RESEARCH PAPER
Biphasic effects of dopamine agonists on haloperiodol induced catalepsy
PC Dandiya, Banerjee Pradeep
January-March 1986, 18(1):9-13
1. At low doses, dopamine agonists, apomorphine (0.25-0.5 mg/kg), lisuride (0.001-0.01 mg/kg) and pergolide (0.005-0.01 mg/kg) lowered the latency period of haloperidol (0.25 mg/kg) induced catalepsy in rats. However, when higher doses were given, apomorphine (5.0-10.0 mg/kg) lisuride (0.05-0.1 mg/kg) and pergolide (0.25-1.0 mg/kg) increased the latency period. 2. Pretreatment with low doses of haloperidol(0.025-0.05mg/kg) partially prevented the lowering of the latency period due to low doses of dopamine agonists. 3. These findings tend to provide one more evidence to confirm that more than one group of dopamine receptors are involved in this typical biphasic response.
[ABSTRACT]   Full text not available  [PDF]
  1,980 140 -
CONFERENCE ABSTRACTS
Abstracts of the Papers, Eighteenth Annual Conference, January 8-10, 1986, JIPMER, Pondicherry
IPS
January-March 1986, 18(1):19-60
Full text not available  [PDF]
  1,129 707 -
RESEARCH PAPER
Role of nervous system in experimental myocardial ischaemia in dogs
DN Das, G Das, Gupta, PK Das
January-March 1986, 18(1):1-8
1. Coronary ligatjon (CL) in dogs produced ventricular fibrillation (VF) in 80% animals, myocardial glycogenolysis and increased cholinesterase (ChE) activity of myocardium and blood. 2. Pretreatment with morphine sulphate significantly reduced the incidence of CL-induced VF and prevented the biochemical changes induced by ischaemia. 3. Pretreatment with atropine methiodide or bilateral vagotomy failed to affect the incidence of CL-induced VF significantly, but increased the ischaemiai-induced depletion of the ventricular myocardial glycogen content. 4. The results indicated that neither genesis nor prevention of VF followi'ng myocardial ischaemia (MI) were related to the haemodynamic and biochemical changes in the myocardium. 5. The anti-arrhythmic activity of narcotic analgesics are probably due to their central actions. 6. The central nervous system and the adrenergic system seem to play important role in the genesis of post-ischaemic arrhythmias, while the cholinergic system appears to have a cardio-protective action.
[ABSTRACT]   Full text not available  [PDF]
  1,164 70 -
Confirmation of the dopamine agonists activity of newly synthesised analogs using biochemical methods
Kuruvilla Alice, Furtell Richard, Uretsky Norman
January-March 1986, 18(1):14-18
1. Two newly synthesised sulfonium analogs have been tested for their dopamine agonist activity using biochemical methods. 2. Addition of dopamine and the analogs caused an increase in cyclic AMPproduction in a dose dependent manner in rat striatal slices. 3. Fluphenazine the dopamine antagonist when added to the incubation medium inhibited the increase in cyclic AMP levels produced by dopamine and the analogs. 4. Dopamine and apomorphine, the known agonists produced inhibition of 3H -ADTN binding to rat brain homogenates. Both the slufonium analogs also produced, inhibition of 3H - ADTN binding to rat brain homogenates. 5. The IC50 values of these two analogs (6.5 uM and 2uM) were higher than that of dopamine (188nM) and apomorphine (20nM).
[ABSTRACT]   Full text not available  [PDF]
  1,084 66 -
Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow