Indian Journal of Pharmacology Home 

SHORT COMMUNICATION
[View FULLTEXT] [Download PDF]
Year : 2021  |  Volume : 53  |  Issue : 3  |  Page : 226--228

Can emapalumab be life saving for refractory, recurrent, and progressive cytokine storm caused by COVID-19, which is resistant to anakinra, tocilizumab, and Janus kinase inhibitors

Erkan Cure1, Adem Kucuk2, Medine Cumhur Cure3 
1 Department of Internal Medicine, Ota and Jinemed Hospital, Istanbul, Turkey
2 Department of Rheumatology, Meram Tip Faculty, Necmettin Erbakan University, Konya, Turkey
3 Department of Biochemistry, Private Kucukcekmece Hospital, Istanbul, Turkey

Correspondence Address:
Dr. Erkan Cure
Department of Internal Medicine, Ota and Jinemed Hospital, Muradiye Mahallesi Nuzhetiye Cad, Deryadil Sokagi No: 1, Istanbul 34357
Turkey

Although many potent drugs have been used for cytokine storm, mortality is high for patients with coronavirus disease-2019 (COVID-19), which is followed up in the intensive care unit. Interferons (IFNs) are the major cytokines of the antiviral defense system released from many cell types. However, IFN-γ plays a key role in both primary and secondary cytokine storms. If the cytokine storm is not treated urgently, it will be fatal; therefore, it should be treated immediately. Anakinra, an interleukin-1 (IL-1) antagonist, tocilizumab, an IL-6 antagonist, and Janus kinase (JAK) inhibitors are successfully used in cytokine storm caused by COVID-19. However, sometimes, despite these treatments, the patient's clinical course does not improve. Emapalumab (Eb) is the human immunoglobulin G1 monoclonal antibody and is a potent and noncompetitive antagonist of IFN-γ. Eb can be life saving for cytokine storm caused by COVID-19, which is resistant to anakinra, tocilizumab, and JAK inhibitors.


How to cite this article:
Cure E, Kucuk A, Cure MC. Can emapalumab be life saving for refractory, recurrent, and progressive cytokine storm caused by COVID-19, which is resistant to anakinra, tocilizumab, and Janus kinase inhibitors.Indian J Pharmacol 2021;53:226-228


How to cite this URL:
Cure E, Kucuk A, Cure MC. Can emapalumab be life saving for refractory, recurrent, and progressive cytokine storm caused by COVID-19, which is resistant to anakinra, tocilizumab, and Janus kinase inhibitors. Indian J Pharmacol [serial online] 2021 [cited 2021 Nov 30 ];53:226-228
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2021;volume=53;issue=3;spage=226;epage=228;aulast=Cure;type=0