Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats
Venugopala Rao Konda1, Madhavi Eerike1, R Prasanth Chary2, Ruckmani Arunachalam1, Venkata Ramana Yeddula3, Vinayak Meti1, T Sobita Devi1
1 Department of Pharmacology, Chettinad Hospital and Research Institute, Chennai, Tamil Nadu, India
2 Department of Pharmacology, BKL Walawalkar Rural Medical College, Ratnagiri, Maharashtra, India
3 Department of Pharmacology, Basaveshwara Medical College, Chitradurga, Karnataka, India
OBJECTIVES: The objectives of the study were to assess evaluate the effects of aluminum chloride (AlCl3) on blood glucose and lipid levels in normal, diabetic, and glibenclamide-treated diabetic rats.
MATERIALS AND METHODS: Forty-two male Wistar rats were divided into seven groups of six each. Group I was normal control, Groups II and III were given AlCl350 and 100 mg/kg, and Group IV to VII were administered with streptozotocin (STZ) (60 mg/kg) intraperitoneally. Group IV was diabetic control, Group V in addition was given AlCl350 mg/kg, Group VI glibenclamide (10 mg/kg), and Group VII glibenclamide and AlCl3(50 mg/kg) per-oral daily for 28 days. Blood glucose and lipid levels were estimated at base line, after diabetes was set in and on the last day of study. Histopathological changes in pancreas, liver, and kidney were studied.
RESULTS: No significant change was observed in blood glucose and lipid levels in Group I. Group II and III showed a dose-dependent significant increase in blood glucose was observed. Group V had a reduction in blood glucose but not to the nondiabetic level. Group VI had significant reduction in blood sugar. In Group VII, treated with glibenclamide and AlCl3, there was no significant change in blood glucose reduction compared to Group VI. Lipid levels were reduced in groups treated with AlCl3and glibenclamide and not in other groups. Gross tissue damage was seen in pancreas in STZ group and in liver and kidney in AlCl3groups.
CONCLUSION: AlCl3administration in Wistar rats caused in significant hyperglycemia in normal rats, hypoglycemia in diabetic rats, and did not influenced hypoglycemic effect of glibenclamide and in addition, resulted in reduction in lipid levels.
Dr. Madhavi Eerike
Department of Pharmacology, Chettinad Hospital and Research Institute, Kelambakkam, Chennai, Tamil Nadu
|How to cite this article:|
Konda VR, Eerike M, Chary R P, Arunachalam R, Yeddula VR, Meti V, Devi T S. Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats.Indian J Pharmacol 2017;49:357-365
|How to cite this URL:|
Konda VR, Eerike M, Chary R P, Arunachalam R, Yeddula VR, Meti V, Devi T S. Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats. Indian J Pharmacol [serial online] 2017 [cited 2020 Oct 30 ];49:357-365
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2017;volume=49;issue=5;spage=357;epage=365;aulast=Konda;type=0