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Year : 2017  |  Volume : 49  |  Issue : 4  |  Page : 317--321

Renal mitochondria can withstand hypoxic/ischemic injury secondary to renal failure in uremic rats pretreated with sodium thiosulfate

Dhivya Mohan, Eswari Dhivya Balasubramanian, Sriram Ravindran, Gino A Kurian 
 Vascular Biology Laboratory, SASTRA University, Thanjavur, Tamil Nadu, India

Correspondence Address:
Gino A Kurian
Vascular Biology Laboratory, Sastra University, Thanjavur - 613 401, Tamil Nadu
India

BACKGROUND: Sodium thiosulfate (STS) is a potent drug used to treat calcific uremic arteriopathy in dialysis patients and its mode of action is envisaged by calcium chelation and antioxidant potential. STS's action on mitochondrial dysfunction, one of the major players in the pathology of vascular calcification is yet to be explored. METHODS: Adenine (0.75%, 28 days)-treated vascular calcified rat kidney was used to isolate mitochondria, where the animal was administered with or without STS for 28 days. Isolated mitochondria were subjected to physiological oxidative stress by nitrogen gas purging (hypoxia/ischemia-reperfusion injury) to assess mitochondrial recovery extent due to STS treatment in vascular calcified rat kidney. RESULTS: The results confirmed an elevated oxidative stress and deteriorated mitochondrial enzyme activities in all groups except the drug-treated group. CONCLUSION: The STS treatment, besides rendering renal protection against adenine-induced renal failure, also helped to maintain mitochondrial functional integrity in a later insult due to hypoxia/ischemia-reperfusion injury.


How to cite this article:
Mohan D, Balasubramanian ED, Ravindran S, Kurian GA. Renal mitochondria can withstand hypoxic/ischemic injury secondary to renal failure in uremic rats pretreated with sodium thiosulfate.Indian J Pharmacol 2017;49:317-321


How to cite this URL:
Mohan D, Balasubramanian ED, Ravindran S, Kurian GA. Renal mitochondria can withstand hypoxic/ischemic injury secondary to renal failure in uremic rats pretreated with sodium thiosulfate. Indian J Pharmacol [serial online] 2017 [cited 2021 Oct 24 ];49:317-321
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2017;volume=49;issue=4;spage=317;epage=321;aulast=Mohan;type=0