Hemorheological effects of amlodipine in spontaneously hypertensive rats
Aleksandr Y Shamanaev, Oleg I Aliev, Anna M Anishchenko, Anastasia V Sidehmenova, Mark B Plotnikov
Department of Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia
OBJECTIVES: The effect of course administration of amlodipine on whole blood viscosity and on macro- and microrheological parameters was evaluated.
MATERIALS AND METHODS: SHRs were treated intragastrically with amlodipine at a dose of 10 mg/kg for 6 weeks. After finishing the course, hemodynamic and hemorheological parameters were measured.
RESULTS: The antihypertensive treatment with amlodipine resulted in a significant decrease in mean blood pressure by 29% and left ventricular to body weight mass index by 7%. Nevertheless, BV tended to increase. The administration of amlodipine had no effect on PV, plasma fibrinogen concentration, RBC aggregation, and RBC deformability, but hematocrit was higher (by 6%) than it was in control group.
CONCLUSIONS: These results demonstrate that amlodipine has no positive hemorheological improvements when administered to SHRs.
Mark B Plotnikov
634028, Russian Federation, 3 Av. Lenin, Tomsk
|How to cite this article:|
Shamanaev AY, Aliev OI, Anishchenko AM, Sidehmenova AV, Plotnikov MB. Hemorheological effects of amlodipine in spontaneously hypertensive rats.Indian J Pharmacol 2017;49:312-316
|How to cite this URL:|
Shamanaev AY, Aliev OI, Anishchenko AM, Sidehmenova AV, Plotnikov MB. Hemorheological effects of amlodipine in spontaneously hypertensive rats. Indian J Pharmacol [serial online] 2017 [cited 2021 Oct 22 ];49:312-316
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2017;volume=49;issue=4;spage=312;epage=316;aulast=Shamanaev;type=0