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Year : 2016  |  Volume : 48  |  Issue : 4  |  Page : 450--452

Assessment of anxiolytic effect of nerolidol in mice

Rajesh Kumar Goel, Dilpreet Kaur, Priyanka Pahwa 
 Department of Pharmaceutical Sciences and Drug Research, Division of Pharmacology, Punjabi University, Patiala, Punjab, India

Correspondence Address:
Rajesh Kumar Goel
Department of Pharmaceutical Sciences and Drug Research, Division of Pharmacology, Punjabi University, Patiala, Punjab
India

Aim and Objectives: The present study was to assess the anxiolytic effect of nerolidol in mice. Materials and Methods: The anxiolytic activity was examined using the elevated plus maze (EPM) and open field test (OFT), and motor coordination by rotarod test. Thirty Swiss albino mice were divided into five groups of six mice each. Group 1 received vehicle control (normal saline); Group 2 received diazepam (1 mg/kg); Groups 3, 4, and 5 received nerolidol 12.5, 25, and 50 mg/kg, respectively. Results: Nerolidol (12.5, 25, and 50 mg/kg) significantly (P < 0.05) increased the time spent and a number of entries in open arm as compared to vehicle control in EPM test. In OFT, the nerolidol showed a significant (P < 0.05) increase in number of rearings and time spent in center and periphery, suggesting exploratory behavior of animals. Furthermore, nerolidol did not alter the fall down latency in rotarod test. Conclusion: Our findings indicated that nerolidol exerts an anxiolytic effect without altering the motor coordination.


How to cite this article:
Goel RK, Kaur D, Pahwa P. Assessment of anxiolytic effect of nerolidol in mice.Indian J Pharmacol 2016;48:450-452


How to cite this URL:
Goel RK, Kaur D, Pahwa P. Assessment of anxiolytic effect of nerolidol in mice. Indian J Pharmacol [serial online] 2016 [cited 2022 Jan 27 ];48:450-452
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2016;volume=48;issue=4;spage=450;epage=452;aulast=Goel;type=0