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Year : 2015  |  Volume : 47  |  Issue : 4  |  Page : 398--402

Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats

Rupali Arun Patil, Aakash B Makwana 
 Department of Pharmacology, MGV's Pharmacy College, Nashik, Maharashtra, India

Correspondence Address:
Dr. Rupali Arun Patil
Department of Pharmacology, MGVSQs Pharmacy College, Nashik, Maharashtra
India

Aims: The aim of this study was to evaluate the bilirubin lowering and wound healing property of aqueous extract of Calotropis procera (AECP) leaves in Wistar rats. Materials and Methods: Albino Wistar rats of either sex were used for the study. Bilirubin lowering property of C. procera leaves was evaluated using phenylhydrazine and paracetamol as inducing agents followed by measuring the concentration of serum total bilirubin in hyperbilirubinemic rats. Wound healing property was evaluated using incision and excision models by measuring tensile breaking strength, percentage wound contractions, and epithelization days, respectively. Statistical Analysis: Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by DunnettSQs test. Results: AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups. Conclusions: AECP showed significant bilirubin lowering and wound healing property in Wistar rats.


How to cite this article:
Patil RA, Makwana AB. Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats.Indian J Pharmacol 2015;47:398-402


How to cite this URL:
Patil RA, Makwana AB. Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats. Indian J Pharmacol [serial online] 2015 [cited 2021 Jul 24 ];47:398-402
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=4;spage=398;epage=402;aulast=Patil;type=0