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Single intramuscular injection of diclofenac sodium in febrile pediatric patients
Jun Yeol Lee1, Jun Hwi Cho1, Myoung Cheol Shin1, Taek Geun Ohk1, Hui Young Lee2, Chan Woo Park1
1 Department of Emergency Medicine, Kangwon National University Hospital, College of Medicine, Kangwon National University, Chuncheon-si, Republic of Korea
2 Department of Internal Medicine, Kangwon National University Hospital, College of Medicine, Kangwon National University, Chuncheon-si, Republic of Korea
Correspondence Address:
Dr. Chan Woo Park
Department of Emergency Medicine, Kangwon National University Hospital, College of Medicine, Kangwon National University, Chuncheon-si
Republic of Korea
Objectives: There are few reports on the effectiveness and safety of intramuscular (IM) antipyretic injections in pediatric patients. This study reports the efficacy and adverse effects of a single IM injection of diclofenac sodium in pediatric patients.
Materials and Methods : This was an observational study in which records of febrile pediatric patients presenting to the emergency department were analyzed. Subjects included pediatric patients presenting to the emergency department with a temperature of 38°C or higher. Infants under 12 months of age were excluded. Patients were excluded if they received antipyretics within 4 h prior to presenting to the emergency department.
Body temperature was measured at 30-60 min intervals following diclofenac sodium injections. Fever alleviation was defined as the temperature decline to 1°C below the temperature at presentation. Patients who received diclofenac sodium twice or more on different days were observed for side effects such as allergic reaction. Records from the emergency department and outpatient clinics were analyzed.
Results : The dose of diclofenac sodium injected was approximately 2 mg/kg. The average time elapsed until antipyresis was 69.1 ± 23.8 min. The average temperature reduction after 1 h was 1.1 ± 0.6°C. The average proportion of temperature change after 1 h was 40.6 ± 22.2%. During the period at the emergency department, there were no reported serious side effects.
Conclusions : A single dose of diclofenac sodium provided effective antipyresis in pediatric patients. Serious side effects were not observed.
How to cite this article:
Lee JY, Cho JH, Shin MC, Ohk TG, Lee HY, Park CW. Single intramuscular injection of diclofenac sodium in febrile pediatric patients.Indian J Pharmacol 2015;47:275-279
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How to cite this URL:
Lee JY, Cho JH, Shin MC, Ohk TG, Lee HY, Park CW. Single intramuscular injection of diclofenac sodium in febrile pediatric patients. Indian J Pharmacol [serial online] 2015 [cited 2023 Sep 27 ];47:275-279
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=3;spage=275;epage=279;aulast=Lee;type=0 |
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