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Year : 2015  |  Volume : 47  |  Issue : 3  |  Page : 248--255

Reversing resistance: The next generation antibacterials

Neel Jayesh Shah 
 Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Correspondence Address:
Dr. Neel Jayesh Shah
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry

Irrational antibiotic usage has led to vast spread resistance to available antibiotics, but we refuse to slide back to DQpreantibiotic era.DQ The threat is serious with the DQEnterococcus, Staphylococcous, Klebsiella, Acinetobacter, Pseudomonas and EnterobacterDQ organisms causing nosocomial infections that are difficult to treat because of the production of extended spectrum β-lactamases, carbapenamases and metallo-β-lactamases. Facing us is a situation where soon multidrug resistance would have spread across the globe with no antibiotics to withstand it. The infectious disease society of America and Food and Drug Administration have taken initiatives like the 10 × SQ20 where they plan to develop 10 new antibiotics by the year 2020. Existing classes of antibiotics against resistant bacteria include the carbapenems, oxazolidinones, glycopeptides, monobactams, streptogramins and daptomycin. Newer drugs in existing classes of antibiotics such as cephalosporins, aminoglycosides, tetracyclines, glycopeptides and β-lactamase inhibitors continue to get synthesized. The situation demands newer targets against bacterial machinery. Some of them include the peptidoglycantransferase, outer membrane protein of Pseudomonas, tRNA synthase, fatty acid synthase and mycobacterial ATP synthase. To curb the irrational and excessive usage of presently available antibiotics should be a priority if they are still to be kept in usage for the future.

How to cite this article:
Shah NJ. Reversing resistance: The next generation antibacterials.Indian J Pharmacol 2015;47:248-255

How to cite this URL:
Shah NJ. Reversing resistance: The next generation antibacterials. Indian J Pharmacol [serial online] 2015 [cited 2023 Sep 30 ];47:248-255
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