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A critical review of pharmacological significance of Hydrogen Sulfide in hypertension
Ashfaq Ahmad1, Munavvar A Sattar1, Hassaan A Rathore1, Safia Akhtar Khan1, MI Lazhari1, Sheryar Afzal1, F Hashmi1, Nor A Abdullah2, Edward J Johns3
1 Department of Physiology, School of Pharmaceutical Sciences, University Sains Malaysia, Penang 11800, Malaysia
2 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
3 Department of Physiology, University College Cork, Cork, Ireland
Correspondence Address:
Dr. Munavvar A Sattar
Department of Physiology, School of Pharmaceutical Sciences, University Sains Malaysia, Penang 11800
Malaysia
In the family of gas transmitters, hydrogen sulfide (H 2 S) is yet not adequately researched. Known for its rotten egg smell and adverse effects on the brain, lungs, and kidneys for more than 300 years, the vasorelaxant effects of H 2 S on blood vessel was first observed in 1997. Since then, research continued to explore the possible therapeutic effects of H 2 S in hypertension, inflammation, pancreatitis, different types of shock, diabetes, and heart failure. However, a considerable amount of efforts are yet needed to elucidate the mechanisms involved in the therapeutic effects of H 2 S, such as nitric oxide-dependent or independent vasodilation in hypertension and regression of left ventricular hypertrophy. More than a decade of good repute among researchers, H 2 S research has certain results that need to be clarified or reevaluated. H 2 S produces its response by multiple modes of action, such as opening the ATP-sensitive potassium channel, angiotensin-converting enzyme inhibition, and calcium channel blockade. H 2 S is endogenously produced from two sulfur-containing amino acids L-cysteine and L-methionine by the two enzymes cystathionine γ lyase and cystathionine β synthase. Recently, the third enzyme, 3-mercaptopyruvate sulfur transferase, along with cysteine aminotransferase, which is similar to aspartate aminotransferase, has been found to produce H 2 S in the brain. The H 2 S has interested researchers, and a great deal of information is being generated every year. This review aims to provide an update on the developments in the research of H 2 S in hypertension amid the ambiguity in defining the exact role of H 2 S in hypertension because of insufficient number of research results on this area. This critical review on the role of H 2 S in hypertension will clarify the gray areas and highlight its future prospects.
How to cite this article:
Ahmad A, Sattar MA, Rathore HA, Khan SA, Lazhari M I, Afzal S, Hashmi F, Abdullah NA, Johns EJ. A critical review of pharmacological significance of Hydrogen Sulfide in hypertension.Indian J Pharmacol 2015;47:243-247
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How to cite this URL:
Ahmad A, Sattar MA, Rathore HA, Khan SA, Lazhari M I, Afzal S, Hashmi F, Abdullah NA, Johns EJ. A critical review of pharmacological significance of Hydrogen Sulfide in hypertension. Indian J Pharmacol [serial online] 2015 [cited 2023 Sep 26 ];47:243-247
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=3;spage=243;epage=247;aulast=Ahmad;type=0 |
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