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Year : 2015  |  Volume : 47  |  Issue : 2  |  Page : 181--184

Comparison of the efficacy of liraglutide with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycaemia in albino rats

K Vinodraj1, IM Nagendra Nayak1, J Vikram Rao1, Paul Mathai1, N Chandralekha1, B Nitasha1, D Rajesh1, TK Chethan2 
1 Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India
2 Department of Community Medicine, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India

Correspondence Address:
K Vinodraj
Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka
India

Objectives: To evaluate the efficacy of liraglutide with pioglitazone for prevention of dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycemia in Albino rats. Materials and Methods: There were four groups of six rats each. First group received dexamethasone alone in a dose of 8 mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received liraglutide 1.8 mg/kg subcutaneously 6 days before dexamethasone and 6 days during dexamethasone administration. Third group received pioglitazone 45 mg/kg orally 6 days before dexamethasone and 6 days during dexamethasone administration. Fourth group did not receive any medication and was considered as normal control. Fasting blood sugar, lipid profile, blood sugar 2 h after glucose load were measured. Liver weight, liver volume, and histopathological analysis were done. Results: Dexamethasone caused hepatomegaly, dyslipidemia, and hyperglycemia. Both pioglitazone and liraglutide significantly reduced hepatomegaly, dyslipidemia and hyperglycemia (P < 0.01). Reduction of blood sugar levels after glucose load was significant with pioglitazone when compared with liraglutide (P < 0.01). Conclusion: Liraglutide has comparable efficacy to pioglitazone in prevention of dexamethasone induced hepatomegaly, dyslipidemia and fasting hyperglycemia.


How to cite this article:
Vinodraj K, Nagendra Nayak I M, Rao J V, Mathai P, Chandralekha N, Nitasha B, Rajesh D, Chethan T K. Comparison of the efficacy of liraglutide with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycaemia in albino rats.Indian J Pharmacol 2015;47:181-184


How to cite this URL:
Vinodraj K, Nagendra Nayak I M, Rao J V, Mathai P, Chandralekha N, Nitasha B, Rajesh D, Chethan T K. Comparison of the efficacy of liraglutide with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycaemia in albino rats. Indian J Pharmacol [serial online] 2015 [cited 2021 Feb 25 ];47:181-184
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=2;spage=181;epage=184;aulast=Vinodraj;type=0