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Year : 2014  |  Volume : 46  |  Issue : 6  |  Page : 617--621

Neuroprotective effect of Feronia limonia on ischemia reperfusion induced brain injury in rats

Purushottam B Rakhunde, Sana Saher, Syed Ayaz Ali 
 Department of Pharmacology, Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, Maharashtra, India

Correspondence Address:
Syed Ayaz Ali
Department of Pharmacology, Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad, Maharashtra
India

Objectives: Brain stroke is a leading cause of death without effective treatment. Feronia limonia have potent antioxidant activity and can be proved as neuroprotective against ischemia-reperfusion induced brain injury. Materials and Methods: We studied the effect of methanolic extract of F. limonia fruit (250 mg/kg, 500 mg/kg body weight, p.o.) and Vitamin E as reference standard drug on 30 min induced ischemia, followed by reperfusion by testing the neurobehavioral tests such as neurodeficit score, rota rod test, hanging wire test, beam walk test and elevated plus maze. The biochemical parameters, which were measured in animals brain were catalase, superoxide dismutase (SOD), malondialdehyde and nitric oxide in control and treated rats. Results: The methanolic extract of F. limonia fruit (250 mg/kg, 500 mg/kg body weight, p.o.) treated groups showed a statistically significant improvement in the neurobehavioral parameters such as motor performance (neurological status, significant increase in grasping ability, forelimb strength improvement in balance and co-ordination). The biochemical parameters in the brains of rats showed a significant reduction in the total nitrite (P < 0.01) and lipid peroxidation (P < 0.01), also a significant enhanced activity of enzymatic antioxidants such as catalase (P < 0.01) and SOD (P < 0.05). Conclusion: These observations suggest the neuroprotective and antioxidant activity of F. limonia and Vitamin E on ischemia reperfusion induced brain injury and may require further evaluation.


How to cite this article:
Rakhunde PB, Saher S, Ali SA. Neuroprotective effect of Feronia limonia on ischemia reperfusion induced brain injury in rats.Indian J Pharmacol 2014;46:617-621


How to cite this URL:
Rakhunde PB, Saher S, Ali SA. Neuroprotective effect of Feronia limonia on ischemia reperfusion induced brain injury in rats. Indian J Pharmacol [serial online] 2014 [cited 2021 Sep 20 ];46:617-621
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2014;volume=46;issue=6;spage=617;epage=621;aulast=Rakhunde;type=0