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Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice
Saroj Kothari1, Anjali Kushwah1, Dilip Kothari2
1 Department of Pharmacology, Gajara Raja Medical College, Gwalior, Madhya Pradesh, India
2 Department of Anaesthesia, Gajara Raja Medical College, Gwalior, Madhya Pradesh, India
Correspondence Address:
Saroj Kothari
Department of Pharmacology, Gajara Raja Medical College, Gwalior, Madhya Pradesh
India
Objective: To study analgesic activity and to evaluate the involvement of opioid and monoamines in the antinociceptive activity of methanol extract of leaves of Aegle marmelos.
Materials and Methods: Analgesic activity of methanol extract (ME) of A. marmelos alone (75,150 and 300mg/kg orally) and in combination with morphine or venlafaxine (subanalgesic) were studied using tail flick test and acetic acid-induced writhing in mice. The effect of pre-treatment with opioid antagonist naltrexone 1mg/kg was also studied on antinociception induced due to ME.
Result: ME produced a dose-dependent significant antinociceptive activity in the tail flick test and acetic acid-induced writhing in mice. (P<0.05) Administration of subanalgesic dose of ME with morphine or venlafaxine also resulted in significant (P<0.05) antinociceptive activity in both the pain models. Pre-treatment with naltrexone inhibited analgesic activity induced by ME alone and combination with morphine or venlafaxine.
Conclusion: A.marmelos in induced antinociception is mediated through both opioid and monoaminergic pain pathways, suggest its possible use in chronic pain.
How to cite this article:
Kothari S, Kushwah A, Kothari D. Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice.Indian J Pharmacol 2013;45:371-375
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How to cite this URL:
Kothari S, Kushwah A, Kothari D. Involvement of opioid and monoaminergic pain pathways in Aegle marmelos induced analgesia in mice. Indian J Pharmacol [serial online] 2013 [cited 2022 Aug 13 ];45:371-375
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2013;volume=45;issue=4;spage=371;epage=375;aulast=Kothari;type=0 |
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