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Year : 2013  |  Volume : 45  |  Issue : 3  |  Page : 293--294

Perforated duodenal ulcer: A rare complication of deferasirox in children

Sunil Kumar Yadav, Vipul Gupta, Ashraf El Kohly, Wasmi Al Fadhli 
 Department of Pediatric Surgery, IBN Sina Hospital, Kuwait

Correspondence Address:
Sunil Kumar Yadav
Department of Pediatric Surgery, IBN Sina Hospital
Kuwait

Duodenal ulcer perforation in pediatric age group is an uncommon entity; hence, it is not usually considered in the differential diagnosis of acute abdomen in these patients. It is important for the emergency physician to consider perforated peptic ulcer in the differential diagnosis of children presenting with acute abdominal pain, gastrointestinal bleeding, or shock. We report a 6½-year-old male child with thalassemia major who presented to emergency room with an acute abdomen and shock, who was subsequently found to have a perforated duodenal ulcer, probably related to use of oral chelating agent, deferasirox. Although, gastrointestinal symptoms like nausea, vomiting, and abdominal pain has been mentioned as infrequent adverse event in the scientific product information of deferasirox, in our current knowledge this is the first case report of perforated duodenal ulcer after oral deferasirox. The severity of this event justifies the reporting of this case. This patient had an atypical presentation in that there were no signs or symptoms of peptic ulcer disease before perforation and shock he was successfully managed with open surgery after initial resuscitation and stabilization of his general condition.


How to cite this article:
Yadav SK, Gupta V, El Kohly A, Al Fadhli W. Perforated duodenal ulcer: A rare complication of deferasirox in children.Indian J Pharmacol 2013;45:293-294


How to cite this URL:
Yadav SK, Gupta V, El Kohly A, Al Fadhli W. Perforated duodenal ulcer: A rare complication of deferasirox in children. Indian J Pharmacol [serial online] 2013 [cited 2023 Feb 3 ];45:293-294
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2013;volume=45;issue=3;spage=293;epage=294;aulast=Yadav;type=0