Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease,Jayanti P Behera1, Bisweswar Mohanty2, Y Roja Ramani1, Bandana Rath1, Supriya Pradhan1: Indian Journal of Pharmacology

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Year : 2012 \| Volume : 44 \| Issue : 5 \| Page : 614--618

Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease

Jayanti P Behera¹, Bisweswar Mohanty², Y Roja Ramani¹, Bandana Rath¹, Supriya Pradhan¹
¹ Department of Pharmacology, MKCG Medical College, Berhampur, Odisha, India
² Department of Pharmacology, Officer Grade II, Sun Pharma, Sikkim, India

Correspondence Address:
Jayanti P Behera
Department of Pharmacology, MKCG Medical College, Berhampur, Odisha
India

Objective: The present study was designed to evaluate the effect of Aegle marmelos unripe fruit extract (AMFE) on inflammatory bowel disease (IBD) in Wistar albino rats. Materials and Methods: Effect of AMFE was studied on acetic acid induced ulcerative colitis (1 ml of 4% acetic acid solution, transrectal) and indomethacin-induced enterocolitis (10 mg/kg, single dose, p.o) in Wistar albino rats. The extract was administered orally at different dose of 150, 200 and 250 mg/kg body weight. Disease pathogenesis was assessed by measuring disease activity index (DAI), macroscopic score, microscopic score, mesenteric mast cell protection, superoxide dismutase (SOD), and malonaldehyde (MDA) levels in the above two models. Results: The results showed a dose dependent decrease in intestinal inflammation following treatment with AMFE. Significant protection in mast cell degranulation was observed in acetic acid and indomethacin-induced IBD models. Treatment with AMFE significantly decreased the MDA levels and increased SOD activity. Conclusion: In our study, AMFE produced anti-inflammatory, antioxidant, and mast cell stabilizing effects demonstrating protective effect in inflammatory bowel disease.

How to cite this article:
Behera JP, Mohanty B, Ramani Y R, Rath B, Pradhan S. Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease.Indian J Pharmacol 2012;44:614-618

How to cite this URL:
Behera JP, Mohanty B, Ramani Y R, Rath B, Pradhan S. Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease. Indian J Pharmacol [serial online] 2012 [cited 2023 Nov 30 ];44:614-618
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2012;volume=44;issue=5;spage=614;epage=618;aulast=Behera;type=0