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Year : 2012  |  Volume : 44  |  Issue : 3  |  Page : 430-

Fundamentals of Experimental Pharmacology

JD Bhatt 
 Department of Pharmacology, Medical College, Baroda, Gujarat, India

Correspondence Address:
J D Bhatt
Department of Pharmacology, Medical College, Baroda, Gujarat

How to cite this article:
Bhatt J D. Fundamentals of Experimental Pharmacology.Indian J Pharmacol 2012;44:430-430

How to cite this URL:
Bhatt J D. Fundamentals of Experimental Pharmacology. Indian J Pharmacol [serial online] 2012 [cited 2022 Nov 28 ];44:430-430
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Full Text

[AUTHOR:1]M. N. Ghosh

Publishers: Hilton and Company, Kolkata,

5 th Edition, 2011, ISBN 81-902965-0-7 (hard bound), pp. 260.

Subject of pharmacology is continuously undergoing rapid changes in its curriculum due to advances in technology and exploration in several new areas of research. However, animal experiments still hold keys before a new chemical molecule is put into clinical practice. At present, usage of animal for postgraduate examination is partly or completely replaced by either oral assessment or by computerized simulation experiments. It will be difficult for the computers to mimic or reproduce the exact effects as seen in animals or in human volunteers. Thus, an experimental pharmacology using animal models continues to be the starting point for a new drug research.

The book Fundamentals of Experimental Pharmacology by Dr. M. N. Ghosh has really been a cornerstone for postgraduate students and researchers engaged in animal experimentation. It has always been useful for postgraduate students in learning and implementing various techniques of an experimental pharmacology. Since publication of its first edition in 1971, this book is still considered as a must read and is one of the best amongst many new books published recently.

The book has several welcome additions. For example, alternatives to animal experiments are deftly narrated in chapter 26 along with advantages and disadvantages of in vitro and in vivo studies. Also, the molecular biology of genes, genomes and gene knock out is a commendable effort towards current update. Techniques used in molecular biology could be amplified further as they are now commonly used in several advanced laboratories in India. Similarly, chapter on biostatistics has a good coverage of almost all methods used in comparative analysis in experimental pharmacology. Guide to drug doses and concentrations used in lab animals and isolated preparations has covered nearly all the drugs.

Chapter of different receptors needs some update about new receptor agonists and antagonists, available today in clinical practice (e.g. tamsulosin and carvedilol). In chapter 15, there is a need to amplify about pathophysiological role of nitric oxide as it is one of the endogenous molecules, which plays an important role in a number of physiological functions. Also, recently introduced agonists and antagonists or synthesis inhibitors of NO could have been added. Next editions may also include photographs of experimental techniques, flow charts and the newer techniques employed in human volunteers (e.g., non-invasive methods).

Overall, the recent edition promises to be of an immense help to the postgraduate students and teachers of pharmacology. This book continues to be an absolute must for the students and researchers who are genuinely interested in exploring new chemical entities for their further development as a useful new drug.