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Year : 2012  |  Volume : 44  |  Issue : 3  |  Page : 390--392

Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats

Pandya Naitik1, Tigari Prakash1, Dupadahalli Kotresha2, Nadendla Rama Rao3 
1 Department of Pharmacology, Acharya and BM Reddy College of Pharmacy, Bangalore, Karnataka, India
2 Department of Parasitology, University of Malaysia, Kuala Lumpur, India
3 Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

Correspondence Address:
Tigari Prakash
Department of Pharmacology, Acharya and BM Reddy College of Pharmacy, Bangalore, Karnataka
India

To evaluate the effect of an antitumor activity of Terminalia catappa on lipid lowering activity in transplanted fibrosarcoma in Wistar albino rats. Methylcholantherene-induced fibrosarcoma was transplanted in rats. After 30 th day when tumor became palpable, started the treatment of ethanolic extract of Terminalia catappa by orally (250 and 500 mg/kg) for a period of 20 days. The blood sample was collected on 21 st day, and the liver and the kidney were also removed for studying the lipid profile in serum and the tissues. The levels of total cholesterol, triglycerides and very low density lipoprotein (VLDL) were markedly elevated and high density lipoprotein (HDL) was markedly decreased in the serum of tumor bearing rats. Significant alterations were also observed in the lipid profile of liver and kidney. These changes were significantly reversed in Terminalia catappa (500 mg/kg) treated animals. The reversal of altered lipid levels to normal values in rats with experimentally induced tumor was showed antitumor activity by Terminalia catappa.


How to cite this article:
Naitik P, Prakash T, Kotresha D, Rao NR. Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats.Indian J Pharmacol 2012;44:390-392


How to cite this URL:
Naitik P, Prakash T, Kotresha D, Rao NR. Effect of Terminalia catappa on lipid profile in transplanted fibrosarcoma in rats. Indian J Pharmacol [serial online] 2012 [cited 2021 Oct 25 ];44:390-392
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2012;volume=44;issue=3;spage=390;epage=392;aulast=Naitik;type=0