Indian Journal of Pharmacology Home 

REVIEW ARTICLE
[View FULLTEXT] [Download PDF]
Year : 2012  |  Volume : 44  |  Issue : 3  |  Page : 299--303

Molecular mechanism of alcoholic fatty liver

Karuna Rasineni1, Carol A Casey2 
1 Department of Internal Medicine, University of Nebraska Medical Center; The Liver Study Unit, VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA
2 Department of Internal Medicine; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center; The Liver Study Unit, VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA

Correspondence Address:
Karuna Rasineni
Department of Internal Medicine, University of Nebraska Medical Center; The Liver Study Unit, VA Nebraska-Western Iowa Health Care System, Omaha, NE
USA

Ethanol abuse and chronic ethanol consumption remains a major public health problem and is responsible for a high rate of morbidity. Alcohol-induced fatty liver generally begins as hepatic steatosis, and if the cause persists, this invariably progresses to steatohepatitis and cirrhosis. The original biochemical explanation for an alcoholic fatty liver centered on the ability of ethanol metabolism to shift the redox state of the liver and inhibit fatty acid oxidation. Subsequent studies found repression of fatty acid oxidation and that the induction of lipogenesis can occur in alcoholic conditions. Ethanol activates sterol regulatory element binding protein 1, inducing a battery of lipogenic enzymes. These effects may be due in part to inhibition of AMP-dependent protein kinase, reduction in plasma adiponectin or increased levels of TNF-α the liver. They in turn activate lipogenic pathways and inhibit fatty acid oxidation. Besides the fatty acid synthesis and oxidation, ethanol also alters lipid droplet (LD, the storage form of triglycerides, TG) metabolism in hepatocytes and very low-density lipoprotein (VLDL) secretion from liver. Because steatosis is now regarded as a significant risk factor for advanced liver pathology, an understanding of the molecular mechanisms in its etiology provides new therapeutic targets to reverse the alcoholic fatty liver.


How to cite this article:
Rasineni K, Casey CA. Molecular mechanism of alcoholic fatty liver.Indian J Pharmacol 2012;44:299-303


How to cite this URL:
Rasineni K, Casey CA. Molecular mechanism of alcoholic fatty liver. Indian J Pharmacol [serial online] 2012 [cited 2021 Oct 17 ];44:299-303
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2012;volume=44;issue=3;spage=299;epage=303;aulast=Rasineni;type=0