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Year : 2012  |  Volume : 44  |  Issue : 1  |  Page : 82--87

Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats

Vijayalakshmi1, Shalini Adiga1, Priyanka Bhat1, Abhishek Chaturvedi2, KL Bairy1, Shobha Kamath2 
1 Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India
2 Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, Karnataka, India

Correspondence Address:
Shalini Adiga
Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka
India

Objective: Memory loss is universal and is the first symptom to manifest in majority of the patients suffering from Alzheimer«SQ»s disease. This study is designed to investigate the effect of Ferula asafoetida linn. (F. foetida) extract on learning and memory in rats. Materials and Methods: Learning and memory were evaluated using elevated plus maze and passive avoidance paradigm after the oral administration of two doses (200 mg/kg and 400 mg/kg) of F. foetida aqueous extract with rivastigmine as positive control. Brain cholinesterase activity, serum thiols and cholesterol were also estimated. Results: Extract produced significant improvement in memory score i.e. step through latency at 400 mg/kg dose in passive avoidance model (P< 0.05) and dose-dependent improvement of transfer latency in elevated plus maze model (P< 0.001). Dose-dependent inhibition of brain cholinesterase (P< 0.001) and significant improvement in antioxidant levels (P< 0.05) were also noted. Conclusions: Memory enhancing potential of F. foetida can be attributed to acetylcholinesterase inhibiting and antioxidant properties. Hence, dietary usage of F. foetida is beneficial and can also be employed as an adjuvant to existing anti-dementia therapies.


How to cite this article:
Vijayalakshmi, Adiga S, Bhat P, Chaturvedi A, Bairy K L, Kamath S. Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats.Indian J Pharmacol 2012;44:82-87


How to cite this URL:
Vijayalakshmi, Adiga S, Bhat P, Chaturvedi A, Bairy K L, Kamath S. Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats. Indian J Pharmacol [serial online] 2012 [cited 2021 Feb 25 ];44:82-87
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2012;volume=44;issue=1;spage=82;epage=87;aulast=Vijayalakshmi,;type=0