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Year : 2011  |  Volume : 43  |  Issue : 6  |  Page : 718--721

Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat

Aaishwarya B Deshmukh1, Jayvadan K Patel2 
1 Department of Pharmacology, Nootan Pharmacy College, Visnagar- Gujarat, India
2 Department of Pharmaceutics, Nootan Pharmacy College, Visnagar- Gujarat, India

Correspondence Address:
Aaishwarya B Deshmukh
Department of Pharmacology, Nootan Pharmacy College, Visnagar- Gujarat
India

Objective : To assess the renoprotective activity of the water extract of Annona squamosa in 5/6 nephrectomized animals. Materials and Methods : For evaluating the renoprotective effects of Annona squamosa, 5/6 nephrectomized rats were used as a model for renal failure. The effects of hot-water extract of leaves of Annona squamosa L. (A. squamosa) at a dose 300 mg/kg bw on biochemical and urinary parameters like plasma urea, plasma creatinine, and urine creatinine were analyzed. For elucidating its effect on oxidative stress, renal superoxide dismutase (SOD) levels were measured. Results : Nephrectomized rats (5/6) showed a significant rise in plasma urea and creatinine levels with a stable fall in urine creatinine. Treatment with A. squamosa extract (300 mg/kg bw) lead to a significant fall in the plasma urea and creatinine values with partial restoration to normal values along with a significant rise in the activity of SOD. Conclusion : Thus, therapeutic strategies against oxidative stress could be effective in renal diseases. This study provides an indication to investigate further the efficacy of A. squamosa as a novel agent for alleviating renal failure.


How to cite this article:
Deshmukh AB, Patel JK. Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat.Indian J Pharmacol 2011;43:718-721


How to cite this URL:
Deshmukh AB, Patel JK. Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat. Indian J Pharmacol [serial online] 2011 [cited 2021 Sep 27 ];43:718-721
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=6;spage=718;epage=721;aulast=Deshmukh;type=0