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Year : 2011  |  Volume : 43  |  Issue : 6  |  Page : 710--713

Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice

Pooja Sinoriya, R Irchhaiya, Bhawna Sharma, Gayatri Sahu, Santosh Kumar 
 Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

Correspondence Address:
Pooja Sinoriya
Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh
India

Objective : To investigate the anticonvulsant and muscle relxant activity of ethanolic extract of stems of Dendrophthoe falcata in mice. Materials and Methods : The ethanolic extract of stems of D. falcata (100, 300 and 500 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock-induced seizures and muscle relaxant activity at the same dose level using rota rod and traction test in mice. Results : Preliminary phytochemical analysis revealed presence of proteins, carbohydrates, glycosides, steroids, triterpenes, flavonoids, tannins and phenolic compounds. D. falcata ethanolic extract (DFEE) (100, 300 and 500 mg/kg, p.o.) significantly (P<0.001) inhibited seizures induced by MES, reduced the duration of Hind limb tonic extensor phase (HLTE) and a decline in motor coordination. Conclusion : The ethanolic extract possesses anticonvulsant activity and muscle relaxant activity.


How to cite this article:
Sinoriya P, Irchhaiya R, Sharma B, Sahu G, Kumar S. Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice.Indian J Pharmacol 2011;43:710-713


How to cite this URL:
Sinoriya P, Irchhaiya R, Sharma B, Sahu G, Kumar S. Anticonvulsant and muscle relaxant activity of the ethanolic extract of stems of Dendrophthoe falcata (Linn. F.) in mice. Indian J Pharmacol [serial online] 2011 [cited 2021 Sep 23 ];43:710-713
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=6;spage=710;epage=713;aulast=Sinoriya;type=0