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Year : 2011  |  Volume : 43  |  Issue : 6  |  Page : 638--643

Racemic salbutamol and levosalbutamol in mild persistent asthma: A comparative study of efficacy and safety

Rituparna Maiti1, Chenimilla Nagender Prasad2, Jyothirmai Jaida1, Sruthi Mukkisa1, Narendar Koyagura1, Anuradha Palani1 
1 Department of Pharmacology, Prathima Institute of Medical Sciences, Nagunur Road, Karimnagar, Andhra Pradesh, India
2 Department of Pulmonology, Prathima Institute of Medical Sciences, Nagunur Road, Karimnagar, Andhra Pradesh, India

Correspondence Address:
Rituparna Maiti
Department of Pharmacology, Prathima Institute of Medical Sciences, Nagunur Road, Karimnagar, Andhra Pradesh
India

Aim : The effect of monotherapy with racemic salbutamol and levosalbutamol on symptoms, quality of life, and pulmonary function has been assessed and compared in mild persistent asthma. Materials and Methods : A randomized, open, parallel clinical study was conducted on 60 patients of mild persistent asthma. After baseline assessments, salbutamol was prescribed to 30 patients and levosalbutamol to another 30 for 4 weeks. The efficacy variables were change in asthma symptom scoring, pulmonary function test, and Mini Asthma Quality of Life Questionnaire (MiniAQLQ) scoring. At follow-up, the patients were re-evaluated and analyzed by statistical tools. Results : Shortness of breath (P<0.001), chest tightness (P=0.033), wheeze (P=0.01), cough (P=0.024), and overall asthma symptom score (P<0.001) were significantly decreased in the levosalbutamol group in comparison to the salbutamol group. Results of MiniAQLQ revealed that improvement in symptoms (P=0.018), activity limitations (P=0.03), environmental stimuli (P=0.013)-related scoring and overall MiniAQLQ scoring (P<0.001) was statistically significant in the levosalbutamol group. Percentage reversibility of forced expiratory volume at one second (P=0.034), forced vital capacity (P=0.029), peak expiratory flow rate (P=0.0003) was found to be superior in the levosalbutamol group. Conclusion : Levosalbutamol was found to be superior compared to recemic salbutamol in mild persistent asthma.


How to cite this article:
Maiti R, Prasad CN, Jaida J, Mukkisa S, Koyagura N, Palani A. Racemic salbutamol and levosalbutamol in mild persistent asthma: A comparative study of efficacy and safety.Indian J Pharmacol 2011;43:638-643


How to cite this URL:
Maiti R, Prasad CN, Jaida J, Mukkisa S, Koyagura N, Palani A. Racemic salbutamol and levosalbutamol in mild persistent asthma: A comparative study of efficacy and safety. Indian J Pharmacol [serial online] 2011 [cited 2021 Sep 28 ];43:638-643
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=6;spage=638;epage=643;aulast=Maiti;type=0