Effect of alcohol on blood glucose and antioxidant enzymes in the liver and kidney of diabetic rats
KR Shanmugam1, K Mallikarjuna2, K Sathyavelu Reddy1
1 Division of Molecular Biology, Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India
2 Laboratory of Exercise Biochemistry, Taipei Sports Universiy, Taipei City, Taiwan
Objective: Diabetes mellitus affects every organ in the man including eyes, kidney, heart, and nervous system. Alcohol consumption is a widespread practice. As the effects of chronic alcohol consumption on diabetic state have been little studied, this study was conducted with the objective of evaluating the effect of alcohol in diabetic rats.
Materials and Methods: For this study, the rats were divided into five groups (n = 6 in each group): normal control (NC), alcohol treatment (At), diabetic control (DC), diabetic plus alcohol treatment (D + At), diabetic plus glibenclamide treatment (D + Gli). Alcohol treatment was given to the diabetic rats for 30 days. During the period the blood glucose levels, and body weight changes were observed at regular intervals. The antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels were assayed in the liver and kidney tissues.
Results: The blood glucose levels were significantly (P < 0.001) elevated and body weight significantly (P < 0.001) decreased in alcohol-treated diabetic rats. SOD and CAT activities were decreased and the MDA level increased significantly (P < 0.001) in alcohol-treated diabetic rats. Histopathological studies showed that alcohol damages the liver and kidney tissues in diabetic rats.
Conclusion: These finddings concluded that the consumption of alcohol in diabetic rats worsens the condition. So the consumption of alcohol by diabetic subjects may be potentially harmful.
K Sathyavelu Reddy
Division of Molecular Biology, Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh
|How to cite this article:|
Shanmugam K R, Mallikarjuna K, Reddy K S. Effect of alcohol on blood glucose and antioxidant enzymes in the liver and kidney of diabetic rats.Indian J Pharmacol 2011;43:330-335
|How to cite this URL:|
Shanmugam K R, Mallikarjuna K, Reddy K S. Effect of alcohol on blood glucose and antioxidant enzymes in the liver and kidney of diabetic rats. Indian J Pharmacol [serial online] 2011 [cited 2023 Jun 2 ];43:330-335
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=3;spage=330;epage=335;aulast=Shanmugam;type=0