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Year : 2011  |  Volume : 43  |  Issue : 3  |  Page : 236--245

Promising molecular targeted therapies in breast cancer

Radha Munagala1, Farrukh Aqil1, Ramesh C Gupta2 
1 James Graham Brown Cancer Center, University of Louisville, Louisville, USA
2 James Graham Brown Cancer Center, University of Louisville, Louisville;Department of Pharmacology and Toxicology, University of Louisville, Louisville, USA

Correspondence Address:
Radha Munagala
James Graham Brown Cancer Center, University of Louisville, Louisville
USA

In recent years, there has been a significant improvement in the understanding of molecular events and critical pathways involved in breast cancer. This has led to the identification of novel targets and development of anticancer therapies referred to as targeted therapy. Targeted therapy has high specificity for the molecules involved in key molecular events that are responsible for cancer phenotype such as cell growth, survival, migration, invasion, metastasis, apoptosis, cell-cycle progression, and angiogenesis. Targeted agents that have been approved for breast cancer include trastuzumab and lapatinib, directed against human epidermal growth factor receptor 2 (HER2) and bevacizumab, directed against vascular endothelial growth factor (VEGF). Several other targeted agents currently under evaluation in preclinical and clinical trials include inhibitors of epidermal growth factor receptor (EGFR), dual EGFR and HER2 inhibitors, VEGF/VEGFR inhibitors, and agents that interfere with crucial signaling pathways such as PI3K/AKT/mTOR and RAS/MEK/ERK; agents against other tyrosine kinases such as Src, insulin-like growth factor (IGF)/IGF-receptor (IGFR); agents that promote apoptosis such as Poly ADP ribose polymerase inhibitors; agents that target invasion and metastasis such as matrix metalloproteinases inhibitors and others. In this review, we highlight the most promising targeted agents and their combination with mainstream chemotherapeutic drugs in clinical trials.


How to cite this article:
Munagala R, Aqil F, Gupta RC. Promising molecular targeted therapies in breast cancer.Indian J Pharmacol 2011;43:236-245


How to cite this URL:
Munagala R, Aqil F, Gupta RC. Promising molecular targeted therapies in breast cancer. Indian J Pharmacol [serial online] 2011 [cited 2022 Dec 2 ];43:236-245
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=3;spage=236;epage=245;aulast=Munagala;type=0