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Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats
D Champatisingh1, PK Sahu2, A Pal2, GS Nanda1
1 Department of Pharmacology, University Department of Pharmaceutical Sciences, Bhubaneswar-751 004, Orissa, India
2 Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar-751 003, Orissa, India
Correspondence Address:
P K Sahu
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar-751 003, Orissa
India
Objective : To assess the anticataleptic and antiepileptic activity of leaves of Mucuna pruriens in albino rats.
Materials and Methods : Haloperidol-induced catalepsy (HIC), maximum electro-shock (MES) method, pilocarpine-induced Status epilepticus (PISE) and single-dose effect of M. pruriens were employed.
Results : M. pruriens (100 mg/kg) had significant anticataleptic and antiepileptic activity in HIC, MES, and PISE.
Conclusions : M. pruriens extract has the potential to be an anticataleptic and antiepileptic drug. Dopamine and 5-HT may have a role in such activity.
How to cite this article:
Champatisingh D, Sahu P K, Pal A, Nanda G S. Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats.Indian J Pharmacol 2011;43:197-199
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How to cite this URL:
Champatisingh D, Sahu P K, Pal A, Nanda G S. Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats. Indian J Pharmacol [serial online] 2011 [cited 2023 May 30 ];43:197-199
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=2;spage=197;epage=199;aulast=Champatisingh;type=0 |
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