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Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice
A Vijayalakshmi, V Ravichandiran, J Anbu, Malarkodi Velraj, S Jayakumari
Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University, Chennai - 117, Tamil Nadu, India
Correspondence Address:
A Vijayalakshmi
Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University, Chennai - 117, Tamil Nadu
India
Objective : To study the anticonvulsant activity and neurotoxicity of ethanolic extract and ethyl acetate fraction of the rhizome of Smilax china (EESC and EAF, respectively) in mice.
Materials and Methods : The anticonvulsant activities of EESC and EAF were studied against maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures in mice and neurotoxicity was determined using rotarod test.
Results : The duration of hindleg extension in MES test was reduced significantly (P < 0.001) by EESC at a dose level of 400 mg/kg and EAF at both higher dose levels (200 and 400 mg/kg). In PTZ model, the seizure latency was prolonged by all the test groups.
Conclusion : The EESC and EAF may help to control petit mal and grand mal seizures.
How to cite this article:
Vijayalakshmi A, Ravichandiran V, Anbu J, Velraj M, Jayakumari S. Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice.Indian J Pharmacol 2011;43:27-30
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How to cite this URL:
Vijayalakshmi A, Ravichandiran V, Anbu J, Velraj M, Jayakumari S. Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice. Indian J Pharmacol [serial online] 2011 [cited 2023 Sep 28 ];43:27-30
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=1;spage=27;epage=30;aulast=Vijayalakshmi;type=0 |
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