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Year : 2010  |  Volume : 42  |  Issue : 6  |  Page : 409--411

Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn

Padmini Shukla1, P Shukla1, SB Mishra2, B Gopalakrishna3 
1 Pranveer Singh Institute of Technology, Kanpur, India
2 Roorki College of Pharmacy, Roorki, Uttar Pradesh, India
3 R.R. College of Pharmacy, Chikbanawara, Bangalore, India

Correspondence Address:
P Shukla
Pranveer Singh Institute of Technology, Kanpur
India

Objective: This study was designed to evaluate the anti-inflammatory and antipyretic activity of ethyl acetate extract of Vitex leucoxylon Linn. in various animal experimental models. Materials and Methods: Ethyl acetate extract of V. leucoxylon Linn. evaluated for anti-inflammatory activity in carrageenan, mediator-induced rat paw edema, and cotton pellet-induced granuloma model. The antipyretic activity was evaluated by yeast-induced pyrexia model. Results: Single administration of the ethyl acetate extract of V. leucoxylon Linn. at dose of 500 mg/kg p.o. showed significant (P < 0.001) inhibition of rat paw edema. The ethyl acetate extract showed significant antipyretic activity in brewer yeast-induced pyrexia in rats throughout the observation period of 4 h. Conclusion: This study shows that ethyl acetate extract of V. leucoxylon Linn. has significant anti-inflammatory and antipyretic activity.


How to cite this article:
Shukla P, Shukla P, Mishra S B, Gopalakrishna B. Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn.Indian J Pharmacol 2010;42:409-411


How to cite this URL:
Shukla P, Shukla P, Mishra S B, Gopalakrishna B. Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn. Indian J Pharmacol [serial online] 2010 [cited 2020 Oct 25 ];42:409-411
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2010;volume=42;issue=6;spage=409;epage=411;aulast=Shukla;type=0