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Year : 2010  |  Volume : 42  |  Issue : 5  |  Page : 293--296

Kaurenic acid: An in vivo experimental study of its anti-inflammatory and antipyretic effects

Miriam C Sosa-Sequera, Omar Suarez, Nelson L Dalo 
 Research Unit in Experimental Pharmacology, School of Medicine, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Venezuela

Correspondence Address:
Miriam C Sosa-Sequera
Research Unit in Experimental Pharmacology, School of Medicine, Universidad Centroccidental Lisandro Alvarado, Barquisimeto
Venezuela

Objective : This study was designed to investigate the anti-inflammatory and antipyretic effects of kaurenic acid (KA), a tetracyclic diterpenoid carboxylic acid, using in vivo experimental animal models. Material and Methods : The anti-inflammatory activity of KA was evaluated in rats, using egg albumin-induced paw edema (acute test) and Freund«SQ»s complete adjuvant-induced paw edema (subacute test), whereas the antipyretic effect was studied in rabbits by peptone-induced pyresis. Acute and subacute toxicity of KA were analyzed in NMRI mice. Results : KA showed anti-inflammatory and antipyretic properties, and the effect caused was significantly dose-related (P < 0.001) in both cases. The mean lethal doses of KA were 439.2 and 344.6 mg/kg for acute and subacute toxicity, respectively. Conclusion : On the basis of these findings, it may be inferred that KA has an anti-inflammatory and antipyretic potential.


How to cite this article:
Sosa-Sequera MC, Suarez O, Dalo NL. Kaurenic acid: An in vivo experimental study of its anti-inflammatory and antipyretic effects.Indian J Pharmacol 2010;42:293-296


How to cite this URL:
Sosa-Sequera MC, Suarez O, Dalo NL. Kaurenic acid: An in vivo experimental study of its anti-inflammatory and antipyretic effects. Indian J Pharmacol [serial online] 2010 [cited 2022 Jun 27 ];42:293-296
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2010;volume=42;issue=5;spage=293;epage=296;aulast=Sosa-Sequera;type=0