Indian Journal of Pharmacology Home 

RESEARCH ARTICLE
[View FULLTEXT] [Download PDF]
Year : 2009  |  Volume : 41  |  Issue : 3  |  Page : 110--114

Hepatoprotective activity of petroleum ether, diethyl ether, and methanol extract of Scoparia dulcis L. against CCl4-induced acute liver injury in mice

TK Praveen1, S Dharmaraj1, Jitendra Bajaj1, SP Dhanabal1, S Manimaran1, MJ Nanjan1, Rema Razdan2 
1 TIFAC CORE HD, J.S.S College of Pharmacy, Rocklands, Ooty-643 001, Tamilnadu, India
2 Department of Pharmacology, Al Ameen College of Pharmacy, Bangalore-560027, Karnataka, India

Correspondence Address:
M J Nanjan
TIFAC CORE HD, J.S.S College of Pharmacy, Rocklands, Ooty-643 001, Tamilnadu
India

Objectives: The present study was aimed at assessing the hepatoprotective activity of 1:1:1 petroleum ether, diethyl ether, and methanol (PDM) extract of Scoparia dulcis L. against carbon tetrachloride-induced acute liver injury in mice. Materials and Methods: The PDM extract (50, 200, and 800 mg/kg, p.o.) and standard, silymarin (100 mg/kg, p.o) were tested for their antihepatotoxic activity against CCl4-induced acute liver injury in mice. The hepatoprotective activity was evaluated by measuring aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total proteins in serum, glycogen, lipid peroxides, superoxide dismutase, and glutathione reductase levels in liver homogenate and by histopathological analysis of the liver tissue. In addition, the extract was also evaluated for its in vitro antioxidant activity using 1, 1-Diphenyl-2-picrylhydrazyl scavenging assay. Results: The extract at the dose of 800 mg/kg, p.o., significantly prevented CCl4-induced changes in the serum and liver biochemistry (P < 0.05) and changes in liver histopathology. The above results are comparable to standard, silymarin (100 mg/kg, p.o.). In the in vitro 1, 1-diphenyl-2-picrylhydrazyl scavenging assay, the extract showed good free radical scavenging potential (IC 50 38.9 1.0 g/ml). Conclusions: The results of the study indicate that the PDM extract of Scoparia dulcis L. possesses potential hepatoprotective activity, which may be attributed to its free radical scavenging potential, due to the terpenoid constituents.


How to cite this article:
Praveen T K, Dharmaraj S, Bajaj J, Dhanabal S P, Manimaran S, Nanjan M J, Razdan R. Hepatoprotective activity of petroleum ether, diethyl ether, and methanol extract of Scoparia dulcis L. against CCl4-induced acute liver injury in mice.Indian J Pharmacol 2009;41:110-114


How to cite this URL:
Praveen T K, Dharmaraj S, Bajaj J, Dhanabal S P, Manimaran S, Nanjan M J, Razdan R. Hepatoprotective activity of petroleum ether, diethyl ether, and methanol extract of Scoparia dulcis L. against CCl4-induced acute liver injury in mice. Indian J Pharmacol [serial online] 2009 [cited 2021 Sep 28 ];41:110-114
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2009;volume=41;issue=3;spage=110;epage=114;aulast=Praveen;type=0