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Year : 2008  |  Volume : 40  |  Issue : 1  |  Page : 28--31

Antiasthmatic activity of Moringa oleifera Lam: A clinical study

Babita Agrawal, Anita Mehta 
 Department of Pharmacology, L.M. College of Pharmacy, Ahmedabad - 380 009, Gujarat, India

Correspondence Address:
Anita Mehta
Department of Pharmacology, L.M. College of Pharmacy, Ahmedabad - 380 009, Gujarat
India

Abstract

The present study was carried out to investigate the efficacy and safety of seed kernels of Moringa oleifera in the treatment of bronchial asthma. Twenty patients of either sex with mild-to-moderate asthma were given finely powdered dried seed kernels in dose of 3 g for 3 weeks. The clinical efficacy with respect to symptoms and respiratory functions were assessed using a spirometer prior to and at the end of the treatment. Hematological parameters were not changed markedly by treatment with M. oleifera . However, the majority of patients showed a significant increase in hemoglobin (Hb) values and Erythrocyte sedimentation rate (ESR) was significantly reduced. Significant improvement was also observed in symptom score and severity of asthmatic attacks. Treatment with the drug for 3 weeks produced significant improvement in forced vital capacity, forced expiratory volume in one second, and peak expiratory flow rate values by 32.97 6.03%, 30.05 8.12%, and 32.09 11.75%, respectively, in asthmatic subjects. Improvement was also observed in % predicted values. None of the patients showed any adverse effects with M. oleifera . The results of the present study suggest the usefulness of M. oleifera seed kernel in patients of bronchial asthma.



How to cite this article:
Agrawal B, Mehta A. Antiasthmatic activity of Moringa oleifera Lam: A clinical study.Indian J Pharmacol 2008;40:28-31


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Agrawal B, Mehta A. Antiasthmatic activity of Moringa oleifera Lam: A clinical study. Indian J Pharmacol [serial online] 2008 [cited 2021 Oct 26 ];40:28-31
Available from: https://www.ijp-online.com/text.asp?2008/40/1/28/40486


Full Text

Bronchial asthma is a syndrome, characterized by increased responsiveness of trachea and bronchi to various stimuli and manifested by acute, recurrent, and chronic attacks of widespread narrowing of airways. Clinically, asthma is expressed by airway obstruction that involves inflammation of the pulmonary airways and bronchial hyperresponsiveness that is usually reversible. [1] The past decade has witnessed phenomenal increases in the incidences of asthma, asthma-related deaths, and hospitalization. Existing classes of antiasthmatic agents offer a limited variety of action that can be combined in a complementary and additive manner. Individual oral agents act only on a part of the pathogenic process of bronchial asthma. Hence, they may not produce any cure and may not prevent all complications of bronchial asthma. Ayurveda has recommended number of drugs from indigenous plant sources for the treatment of bronchial asthma and other allergic disorders. Moringa oleifera Lam. (Fam: Moringaceae ) ( M. oleifera ) is one such drug, used by many ayurvedic practitioners for the treatment of asthma and chronic rheumatism. [2]

Moringa oleifera is a medium-sized tree, found wild in the sub-Himalayan tract. The plant is reported to elicit good clinical response in children suffering from upper respiratory tract infection and skin infection. Seeds reportedly have purgative, antipyretic, [3] antispasmodic, anti-inflammatory, [4],[5] and diuretic activity. [6] It has been reported that alkaloid from the plant closely resembles ephedrine in action and useful in the treatment of asthma. Alkaloid Moringine relaxes bronchioles. [7] However, no clinical studies have so far been carried out with respect to its efficacy in bronchial asthma. Thus, the objective of the present investigation was to carry out clinical evaluation of M. oleifera to assess its therapeutic potential in asthma.

 Materials and Methods



Seed kernels of M. oleifera were purchased from the local market of Ahmedabad and were identified and authenticated by Department of Pharmacognosy, L.M. College of Pharmacy, Ahmedabad, India. The seeds were powdered and sachets were prepared. An open label, noncomparative clinical study was carried out on 20 patients (17-70 years) of either sex, having mild-to-moderate bronchial asthma, [8] visiting Outpatient Department of Government Ayurvedic Hospital, Ahmedabad, India. The protocol for carrying out the clinical study was approved by the Director, Department of Ayurveda and Homeopathic Medicine, Government of Gujarat, India and also by the institutional ethics committee for the clinical study. Informed consent was obtained from all patients enrolled in the study.

Patients having symptoms of bronchial asthma such as dyspnoea, wheezing, tightness in chest, and cough were enrolled in the study. Patients having breathlessness due to cardiovascular disorders, having very severe bronchial asthma (peak expiratory flow rate [PEFR] M. oleifera . Patient was asked to keep mouthpiece of spirometer in mouth and hold it firmly with the help of lips. Patient was asked to breathe normally a few times then to take in a deep inspiration, as much as he/she can. Then, he/she is immediately instructed to blow out as hard and as fast as possible and keep breathing out till he can do so no more. The spirogram and the values of lung volumes and lung flow rates obtained were recorded. The whole process was repeated three times and the best results were recorded. Parameters assessed were forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow rate (PEFR), and forced expiratory flow rate between 25 and 75% (FEF 25-75% ). Maximum ventilatory volume (MVV) was determined by asking the patient to breathe as hard and fast as possible for 1 min.

The patients were given fine powder of dried seed kernels in a dose of 3 g bid for 3 weeks and were advised to take it with water. Patients were given medication supply for 1 week and were asked to report every week. At weekly visit, patients were asked for occurrence of any untoward effect (if any) and improvement in the symptoms observed. Symptom score was measured for all commonly observed symptoms of bronchial asthma before starting the treatment and at the end of 3 weeks of treatment. Score was graded as 3, 2, 1, and 0 for the presence of severe, moderate, mild, and the absence of any symptom, respectively. [9]

Statistical analysis

The values were expressed as mean SEM. Data were analyzed using Student's paired t-test. The value of ' P ' less than 5% ( P M. oleifera. However, the majority of patients showed significant increase in Hb values and ESR was significantly reduced [Table 2].

Spirometry tests before and after 3 weeks of treatment with M. oleifera revealed significant increase in FVC and FEV1. Mean % increases in FVC and FEV1 were 32.97 6.03% and 30.05 8.12%, respectively [Table 3]. Improvement was also observed in % predicted values. Twenty-five percent of patients were having predicted values of FVC above 80% before treatment with M. oleifera . After treatment with M. oleifera , 40% of patients were found to have predicted values of FVC above 80% [Table 4]. Out of 20 patients, 50% of patients were having FEV1 M. oleifera , which was decreased to 35% of patients [Table 4]. Significant improvement in PEFR, FEF 25-75% , and MVV was observed with M. oleifera . Mean % increase in PEFR was 32.09 [Table 3]. Forty percent had PEFR in the range of 20-40% of the predicted values before treatment with M. oleifera . After treatment, this was decreased to 20% of patients having PEFR M. oleifera suggest that there was appreciable decrease in severity of symptoms of asthma and also simultaneous improvement in lung function parameters. [10] The results of the effect of M. oleifera on four basic symptoms of bronchial asthma (dyspnoea, wheezing, chest tightness, and cough) revealed that score of all symptoms was reduced significantly. According to Unani medical theory, obstructive breathing may be due to a phlegmatic (thick sticky sputum) condition and it is produced mainly in those patients who have phlegmatic temperament. Moringa oleifera fruit is reported to cure kapha. [11] Our results support the effectiveness of M. oleifera in ameliorating the symptoms of bronchial asthma. The results of hematological parameters revealed that the majority of patients showed significant increase in their Hb values. These observations support earlier report that M. oleifera increases Hb levels in rats. [12]

Apart from the improvement in symptoms, M. oleifera was found to significantly improve FVC and FEV1. Forced vital capacity is clinically useful as an index of lung function. Forced expired volume in one second is a useful measure of how fast one can breathe out and full lungs can be emptied. It is the best measure of lung function for assessing airflow limitation or asthma severity. [13] Moringa oleifera also significantly improves PEFR, FEF 25-75% , and MVV. Peak expiratory flow rate is a simple index of pulmonary function used in both research and clinical practice. Response to asthma treatment is usually accompanied by an increase in PEFR value and a decrease in its variability. [14]

Statistically significant increase in lung volumes (FVC and FEV1) and lung flow rates (PEFR, FEF 25-75% , and MVV) suggest the usefulness of M. oleifera in the treatment of bronchial asthma.

Thus, the results of our study suggest that there was appreciable decrease in severity of symptoms of asthma and also simultaneous improvement in respiratory functions. No change in any general parameters and absence of any untoward effect during the course of study suggest the safety of drug in the dose used. Further, the hematological profile showed enhancement in the Hb level. Considering the easy availability, convenience, and its efficacy on oral administration, the seeds of M. oleifera may be considered as a useful drug for bronchial asthma. However, the detailed clinical and experimental studies are required to investigate its mechanism of action and therapeutic utility of these herbs.

 Acknowledgment



Authors are thankful to Government Ayurvedic Hospital, Ahmedabad for extending their help to perform the clinical studies.

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