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Year : 2007  |  Volume : 39  |  Issue : 5  |  Page : 231--234

Pharmacological and biochemical evidence for the antidepressant effect of the herbal preparation Trans-01

Md. Shalam1, SM Shantakumar1, M Laxmi Narasu2 
1 Department of Pharmacology and Pharmachemistry, VL College of Pharmacy, Manikprabhu Temple Road, Raichur - 584 103, Karnataka, India
2 Department of Biotechnology, JNTU University, Hyderabad, Andhra Pradesh, India

Correspondence Address:
Md. Shalam
Department of Pharmacology and Pharmachemistry, VL College of Pharmacy, Manikprabhu Temple Road, Raichur - 584 103, Karnataka
India

In this study, Trans-01, a polyherbal formulation, was explored for its antidepressant properties, using the forced swim test (FST), tail suspension test (TST) and forced swimming stress (FSS)-induced alterations in serum corticosterone levels. For this purpose, the effect different doses of Trans-01 (25, 50, 75 and 100 mg/kg; PO) were studied. Trans-01 was found to safe up to a dose of 5000 mg/kg since no mortality was observed within 48 h of administration. In TST, Trans-01 showed a dose-dependent decrease in immobility time, which is an indication of its antidepressant effect; this finding was further reinforced in the FST, where a significant effect on immobility was witnessed. However, to explore the possible mechanism of action of Trans-01, the FSS was used to induce corticosterone levels; Trans-01 significantly attenuated the elevated corticosteroid levels. A locomotor activity test was carried out to ascertain whether the antidepressant effect of Trans-01 included general body stimulation. These results indicate that Trans-01 can be a potential candidate for managing depression. However further studies are required to substantiate the same which are underway in our lab.


How to cite this article:
Md. Shalam, Shantakumar S M, Narasu M L. Pharmacological and biochemical evidence for the antidepressant effect of the herbal preparation Trans-01.Indian J Pharmacol 2007;39:231-234


How to cite this URL:
Md. Shalam, Shantakumar S M, Narasu M L. Pharmacological and biochemical evidence for the antidepressant effect of the herbal preparation Trans-01. Indian J Pharmacol [serial online] 2007 [cited 2022 Dec 2 ];39:231-234
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2007;volume=39;issue=5;spage=231;epage=234;aulast=Md.;type=0