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Year : 2007  |  Volume : 39  |  Issue : 4  |  Page : 180--183

Immunosuppressive effect of medicinal plants of Kolli hills on mitogen-stimulated proliferation of the human peripheral blood mononuclear cells in vitro

S Arokiyaraj1, K Perinbam1, P Agastian2, K Balaraju2 
1 PG and Research, Sathyabama University, Chennai - 600 119, India
2 Department of Plant Biology and Biotechnology, School of Life Sciences, Loyola College, Chennai - 600 034, India

Correspondence Address:
K Perinbam
PG and Research, Sathyabama University, Chennai - 600 119
India

Four medicinal plant species were collected from the Kolli hills of Tamil Nadu and were screened for their immunosuppressive effect. The plants were shade dried and extracted with methanol. The crude methanol extracts were tested for inhibition of lymphocyte proliferation via lymphocyte proliferation assay by 3thymidine uptake. The test plants were Justicia gendarussa, Plumbago indica, Aloe vera, and Aegle marmelos. Among the plants tested J. gendarussa (100 g/ml) showed the highest lymphocyte inhibition (84%). Sequential extraction of J. gendarussa in various solvents (n-hexane, benzene, ethyl acetate, chloroform, acetone, ethanol, and water) confirmed that all of the above extracts at 50 g/ml, aqueous extract inhibited lymphocyte proliferation. Further, 17 high performance liquid chromatography fractions were collected for the aqueous extract and fraction no. 15 showed maximum inhibition of lymphocyte proliferation. The present study indicates that these extracts should be investigated further for the possible presence of immunosuppressive components.


How to cite this article:
Arokiyaraj S, Perinbam K, Agastian P, Balaraju K. Immunosuppressive effect of medicinal plants of Kolli hills on mitogen-stimulated proliferation of the human peripheral blood mononuclear cells in vitro.Indian J Pharmacol 2007;39:180-183


How to cite this URL:
Arokiyaraj S, Perinbam K, Agastian P, Balaraju K. Immunosuppressive effect of medicinal plants of Kolli hills on mitogen-stimulated proliferation of the human peripheral blood mononuclear cells in vitro. Indian J Pharmacol [serial online] 2007 [cited 2022 Jun 28 ];39:180-183
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2007;volume=39;issue=4;spage=180;epage=183;aulast=Arokiyaraj;type=0