Indian Journal of Pharmacology Home 

RESEARCH PAPER
[View FULLTEXT] [Download PDF]
Year : 2004  |  Volume : 36  |  Issue : 5  |  Page : 284--287

Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage

MG Rajesh, MS Latha 
 School of Biosciences, Mahatma Gandhi University, P. D. Hills, P. O., Kottayam - 686 560, India

Correspondence Address:
M S Latha
School of Biosciences, Mahatma Gandhi University, P. D. Hills, P. O., Kottayam - 686 560
India

OBJECTIVE: To evaluate the potential efficacy of Glycyrrhiza glabra Linn. (Fabaceae) in protecting tissues from peroxidative damage in CCl4-intoxicated rats. MATERIAL AND METHODS: Peroxidative hepatic damage in rats was studied by assessing parameters such as thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD), superoxidedismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px) and glutathione (GSH) in liver and kidneys. The effect of co-administration of G. glabra on the above parameters and histopathological findings of the liver in experimental animals was studied. RESULTS: The increased lipid peroxide formation in the tissues of CCl4-treated rats was significantly inhibited by G. glabra. The observed decreased antioxidant enzyme activities of SOD, CAT, GSH-Px, GST, and antioxidant concentration of glutathione were nearly normalized by G. glabra treatment. Carbon tetrachloride-induced damage produces alteration in the antioxidant status of the tissues, which is manifested by abnormal histopathology. G. glabra restored all these changes. CONCLUSION: Glycyrrhiza glabra is a potential antioxidant and attenuates the hepatotoxic effect of CCl4.


How to cite this article:
Rajesh M G, Latha M S. Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage.Indian J Pharmacol 2004;36:284-287


How to cite this URL:
Rajesh M G, Latha M S. Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage. Indian J Pharmacol [serial online] 2004 [cited 2022 Jun 28 ];36:284-287
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2004;volume=36;issue=5;spage=284;epage=287;aulast=Rajesh;type=0