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Year : 2004  |  Volume : 36  |  Issue : 5  |  Page : 277--283

Calcitonin gene-related peptide: Understanding its role

Srinivas Ghatta, D Nimmagadda 
 Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo ND 58105, USA

Correspondence Address:
Srinivas Ghatta
Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo ND 58105
USA

Calcitonin gene-related peptide (CGRP), a 37 amino acid neuropeptide, identified in multiple species, has widespread distribution and expression. CGRP acts through G protein-coupled receptors whose presence and changes in function modulate the peptide«SQ»s effects in various tissues. Three receptor subtypes have been identified and CGRP«SQ»s signal transduction through the receptors is dependent on two accessory proteins: Receptor activity modifying protein1 (RAMP1) and Receptor component protein (RCP). Several endogenous substances such as glucocorticoids, nitric oxide (NO), nerve growth factors (NGF), and steroid hormones modulate CGRP release and synthesis. Both peptide and non-peptide agonists and antagonists of CGRP receptors are being developed. Also the therapeutic benefits of some antagonists such as BIBN 4096 BS in migraine have been promising. This brief review provides a preliminary understanding of the diverse biological effects of the peptide in various systems. The current status of CGRP and its receptors in many pathophysiological states is not fully explored and future findings are greatly awaited.


How to cite this article:
Ghatta S, Nimmagadda D. Calcitonin gene-related peptide: Understanding its role.Indian J Pharmacol 2004;36:277-283


How to cite this URL:
Ghatta S, Nimmagadda D. Calcitonin gene-related peptide: Understanding its role. Indian J Pharmacol [serial online] 2004 [cited 2022 Jun 28 ];36:277-283
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2004;volume=36;issue=5;spage=277;epage=283;aulast=Ghatta;type=0