Hypoglycemic activity of Ficus hispida (bark) in normal and diabetic albino rats
Rajib Ghosh1, Kh Sharatchandra2, S Rita2, IS Thokchom2
1 Department of Pharmacology, GSL Medical College and Hospital, NH-5, Laxmipuram, Rajahmundry-533 294. East Godavari Dist, Andhra Pradesh, India
2 Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India
OBJECTIVE: To find out the hypoglycemic activity of Ficus hispida Linn. (bark) in normal and diabetic albino rats and to evaluate its probable mechanism of hypoglycemic activity if any.
MATERIAL AND METHODS: Albino rats were divided into groups (n=6) receiving different treatments consisting of vehicle, water-soluble portion of the ethanol extract of Ficus hispida bark (FH) (1.25 g/kg) and standard antidiabetic drugs, glibenclamide (0.5 mg/kg) and 0.24 units of insulin (0.62 ml of 0.40 units/ml). Blood glucose was estimated by the glucose oxidase method in both normal and alloxan-induced diabetic rats before and 2 h after the administration of drugs. To find out the probable mechanism of action of FH as a hypoglycemic agent, i) the glycogen content of the liver, skeletal muscle and cardiac muscle, and ii) glucose uptake by isolated rat hemi-diaphragm were estimated.
RESULTS: FH showed significant reduction of blood glucose level both in the normal (P<0.01) and diabetic (P<0.001) rats. However, the reduction in the blood glucose level was less than that of the standard drug, glibenclamide. FH also increased the uptake of glucose by rat hemi-diaphragm significantly (P<0.001). There was a significant increase in the glycogen content of the liver (P<0.05), skeletal muscle (P<0.01) and cardiac muscle (P<0.001). The amount of glycogen present in the cardiac muscle was more than the glycogen present in the skeletal muscle and liver.
CONCLUSION: FH has significant hypoglycemic activity. Increased glycogenesis and enhanced peripheral uptake of glucose are the probable mechanisms involved in its hypoglycemic activity.
Department of Pharmacology, GSL Medical College and Hospital, NH-5, Laxmipuram, Rajahmundry-533 294. East Godavari Dist, Andhra Pradesh
|How to cite this article:|
Ghosh R, Sharatchandra K, Rita S, Thokchom I S. Hypoglycemic activity of Ficus hispida (bark) in normal and diabetic albino rats.Indian J Pharmacol 2004;36:222-225
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Ghosh R, Sharatchandra K, Rita S, Thokchom I S. Hypoglycemic activity of Ficus hispida (bark) in normal and diabetic albino rats. Indian J Pharmacol [serial online] 2004 [cited 2022 Jan 27 ];36:222-225
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2004;volume=36;issue=4;spage=222;epage=225;aulast=Ghosh;type=0