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Year : 2000  |  Volume : 32  |  Issue : 3  |  Page : 231--234

Investigation into the pharmacological basis for some of the folkloric uses of Bonny light crude oil in Nigeria

OE Orisakwe1, DD Akumka2, OJ Afonne3, KS Gamanniel4 
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Correspondence Address:
O E Orisakwe


Objective: The effects of Bonny light crude oil on the smooth and skeletal muscles contraction and pain were investigated. Methods: Analgesic effect of Bonny light crude oil was tested in mice using acetic acid (0.75%)- induced writhing model. Its effects on histamine-, and Ach-induced smooth muscle contraction were studied in guinea pig ileum. The effects of crude oil on Ach-induced contraction of rat duodenum and frog rectus abdominis muscle were also studied. Results: The crude oil caused complete inhibition of histamine - induced smooth muscle contraction, while producing only a partial inhibition of the acetylcholine - induced contraction. It had no effects on the acetylcholine-induced skeletal muscle contraction, but showed good analgesic effect comparable to aspirin. Conclusion: The Bonny light crude oil possesses inhibitory action on smooth muscle contraction induced by histamine, and analgesic property.


How to cite this article:
Orisakwe O E, Akumka D D, Afonne O J, Gamanniel K S. Investigation into the pharmacological basis for some of the folkloric uses of Bonny light crude oil in Nigeria.Indian J Pharmacol 2000;32:231-234


How to cite this URL:
Orisakwe O E, Akumka D D, Afonne O J, Gamanniel K S. Investigation into the pharmacological basis for some of the folkloric uses of Bonny light crude oil in Nigeria. Indian J Pharmacol [serial online] 2000 [cited 2022 Jun 27 ];32:231-234
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2000;volume=32;issue=3;spage=231;epage=234;aulast=Orisakwe;type=0